how does a glp 1 drug work glp-1_analogs [TUSOM GLP-1 2.0: Where the Next
Description
LBM did not predict final body weight at all (r = 0.03)

Orforglipron also is more likely to increase heart rate (by about 4 beats per minute)
[DOI] [PubMed] [Google Scholar] 57.Amblee A

hazard ratio 1.60, 95% CI 1.37 to 1.87) but not after confounding factors were accounted for (0.91, 0.73 to 1.12)

Capuccio S, Scilletta S, La Rocca F, Miano N, Di Marco M, Bosco G, et al

The jump from 4mg to 8mg is the largest absolute increase in the protocol and typically produces the most intense gastrointestinal adjustment period
