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KFF Health Tracking Poll May 2024: the publics use and views of GLP-1 drugs

315 The results showed that, in the OA rat model, liraglutide could activate the PKA/CREB signaling pathway and inhibit the inflammatory response through this pathway, thereby alleviating OA symptoms

The FDA has been clear on this

doi: 10.1016/j.molmet.2019.09.010 [DOI] [PMC free article] [PubMed] [Google Scholar] 7

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Most studies report the absence [[397], [398], [399]] or very restricted expression of the GLP-1 receptor in a small subset (10%) of -cells [395], and treatment of isolated rat -cells with GLP-1 enhances rather than inhibits the release of glucagon [[604], [605], [606]]