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Description
Consistent with the FAP-based approach, stimulation with PF-06882961 for 30 minutes triggered marked intracellular accumulation of GFP-GLP-1R, which was reversible following a 2-hour washout period

An added benefit of these drugs compared to DPP4 inhibitors is the added weight loss (236) and for some specific GLP-1r agonists (liraglutide and semaglutide) there is a reduction in cardiovascular events (168)

Orforglipron showed similar gastrointestinal side effects as other GLP-1 drugs, with the most common being diarrhea, nausea, indigestion, and constipation
But it's the gastrointestinal issues that might do her in

References Holst, J

Currently, antidepressant medications primarily target serotonin and norepinephrine transporters, but approximately 30-40% of patients do not respond well to these treatments