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Family B GPCRs are important therapeutic targets, however our understanding of their mechanism of action is limited by the lack of structural information on activated and full-length receptors

These are new drugs and we dont therefore have a large amount of clinical data to look at, but there are pharmacokinetic studies which raise concerns

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Creative Biolabs now launches a broad range of Hi-Affi GPCR stable cell lines to study calcium-, cAMP-, DAG-related as well as multiplex pathway events of various GPCRs