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Providers typically evaluate BMI status, presence of obesity-related complications, documented metabolic dysfunction, cardiovascular risk, previous weight-loss interventions, and family history of metabolic disease

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Mol Metab 2018;18:314 [DOI] [PMC free article] [PubMed] [Google Scholar] 55

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Meanwhile, the reward-restricting pathway limits hedonic eating behavior involving the pleasure-responsible mesolimbic system, particularly dopaminergic neurons equipped with 5-HTR 2C [103]

Metabolic syndromea cluster of conditions including elevated blood sugar, blood pressure, triglycerides, and abdominal fatincreasingly qualifies for GLP-1 coverage