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Who Should Exercise Caution Research protocols should be designed with extra caution or retatrutide may be contraindicated in subjects with: Pre-existing tachycardia or arrhythmias (e.g., atrial fibrillation, supraventricular tachycardia) Thyroid conditions, particularly hyperthyroidism (which already elevates heart rate) Use of stimulant compounds (caffeine stacking, sympathomimetic amines) History of heart failure or reduced ejection fraction Concurrent use of other agents known to elevate heart rate Research Note: Retatrutide is not approved for human use

[DOI] [PMC free article] [PubMed] [Google Scholar] 98.Lindqvist A., Shcherbina L., Fischer A.-H.T., Wierup N

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