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10.1016/j.obpill.2024.100127 [DOI] [PMC free article] [PubMed] [Google Scholar] 3.Nauck MA, Meier JJ (2016) The incretin effect in healthy individuals and those with type 2 diabetes: physiology, pathophysiology, and response to therapeutic interventions

Tirzepatide's dual GLP-1 and GIP receptor agonism produces 2025% weight loss in phase-three trials, compared to semaglutide's 1418%, making it particularly effective for patients with genetic predictors of reduced semaglutide response

Diabetes (2017) 66(11):272937.10.2337/dbi17-0021 160 MakishimaMOkamotoAYRepaJJTuHLearnedRMLukAet alIdentification of a nuclear receptor for bile acids

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Tobb explains, leading to mild calorie loss, modest weight reduction and improved blood sugar control
