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Under various pathological conditions such as muscular dystrophy, chronic kidney disease, cancer, liver disease, obesity, and injuries like anterior cruciate ligament (ACL) tears, GDF-8 levels may increase

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This is evidenced by up-regulation of glycolytic enzyme expression, increased rates of glucose uptake and consumption, as well as augmented ATP content, insulin secretion and glycolytic flux after removal of Exendin-4

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