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Moreover, continued investigation into the pleiotropic effects of GLP-1 receptor agonists may reveal other therapeutic possibilities, possibly transforming the management of many metabolic and non-metabolic disorders

I think it's a complacency

Overall, our findings were reminiscent of a previous report describing the 100-fold reduction in the binding affinity of the small-molecule GLP-1R antagonist T-0632 in the W33S mutant of human GLP-1R ( 33 )

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