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Something in the spice fenugreek seemed to boost GLP-1 signaling in a test tube, but there are no human studies, and it didnt even work in mice

It may increase blood pressure, cholesterol problems, insulin resistance, sleep apnea, and the risk of blood clots

[DOI] [PubMed] [Google Scholar] 159.Yang R., Zhang L., Guo J., Wang N., Zhang Q., Qi Z., Wu L., Qin L., Liu T

These developments have far-reaching implications, including intensified efforts to end the sale of compounded GLP-1 drugs altogether
While co-expression of BTRs with CCK-secreting I-cells has not been assessed in humans, oral administration of encapsulated HCl quinine (18 mg) was recently reported to increase plasma CCK concentrations and reduce energy intake at an ad libitum meal in healthy young individuals (62)

Some studies on the effects of GLP-1s in certain sports are now under way
