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While the exact neurochemical link isnt fully mapped out, the overlap between appetite control and mood regulation provides a plausible biological explanation

Located at the basal compartment of the seminiferous epithelium, the BTB is primarily formed by junctional complexes between SC, including tight junctions, gap junctions, and basal ectoplasmic specializations ( During spermatogenesis, spermatogonia migrate across the BTB within the seminiferous tubules, the functional units of the mammalian testis

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N Engl J Med 390(13):11761185