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For triathletes training 10 to 20 hours per week, these drugs can compromise carbohydrate absorption during racing, blunt thirst cues and increase the likelihood of RED-S if nutrition is not carefully managed

Diabetologia (2010) 53(1):1539

Decades of research have highlighted the clinical demerits of abnormally high body weight (BW), with BMIs exceeding 30 kg/m 2 and 40 kg/m 2 correlated with decreased life expectancies of three and 10 years, respectively

Several studies systematically investigating the potential association of GLP-1RAs with bowel obstruction utilized large medical databases

Brenner M

In susceptible populations such as the elderly, persistent hyperglycemia associated with GC use can precipitate hyperglycemic hyperosmolar states, which would require frequent hospital admissions for aggressive hydration and insulin therapy, as well as increased complications related to inpatient hyperglycemia[19]