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This presumably reflects the ability of long-acting GLP-1 analogs to enter the brain at areas with an incomplete BBB, such as the median eminence

For example, the liraglutide clinical trial found that side effects, including mood changes, were about the same for people with bipolar disorder whether they took liraglutide or a placebo

[DOI] [PubMed] [Google Scholar] 25.Nakhla M., Nair A., Balani P., Ujjawal A., Arun Kumar P., Dasari M., Yukselen Z., Bansal K., Ganatra S., Dani S.S

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Semaglutide (Brand names: Ozempic for diabetes, Wegovy for weight management, Rybelsus as an oral tablet) Administered as a weekly injection or a daily pill