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Ghrelin-induced orexigenic effect in rats depends on the metabolic status and is counteracted by peripheral CB1 receptor antagonism

Oral administration of these conjugates significantly improved glucose-lowering effects compared to native GLP-1, with DBP-GLP-1 showing superior efficacy likely attributed to enhanced intestinal absorption

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Consequently, up to 66% of liver transplant recipients are affected by diabetes which has profound impact on liver allograft and patient survival