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doi: 10.1001/jama.2021.23619 [DOI] [PMC free article] [PubMed] [Google Scholar] 102

The highest caution is usually needed in patients who already have moderate to severe retinopathy , diabetic macular edema, or recent unstable retinal disease

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Compounded options like lozenges and drops have less clinical evidence, with results varying more widely from person to person

Neovius et al., 2009