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1 Finally, there is a concern regarding the development of GLP-1 RA antibodies that put patients at risk of hypersensitivity reactions and reduced efficacy

Injectable GLP-1 medications may currently offer stronger weight loss outcomes, but oral options have demonstrated meaningful weight-loss results in clinical studies and may be appropriate depending on individual circumstances

Gentle physical activity and adequate sleep can also help

Furthermore, 86% of the participants treated with semaglutide achieved a weight loss of 5% or more, and 69% achieved a weight loss of 10% or more

Modification of Epicardial Adipose Tissue Epicardial adipose tissue (EAT), which is a store of visceral fat located between the myocardium and pericardium, has been implicated in the pathogenesis of ASCVD and has been shown to confer a pro-inflammatory milieu for the neighbouring coronary arteries [149]

However, emerging data and mechanistic plausibility suggest that certain populations may be at higher risk of suboptimal intake or depletion, particularly with prolonged therapy, rapid weight loss, restricted dietary variety or pre-existing marginal nutrient status