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However, reduced GLP-1/Notch activity causes all GSCs to cease self-renewal/germline proliferation and differentiate as sperm (Glp phenotype) (Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] Rima M., Rima M., Fajloun Z., Sabatier J

However, it must be stressed that, despite the lack of reproductive improvement, even low doses of GLP1/E were sufficient to markedly improve the metabolic perturbations in PWA mice, thus defining an optimal scenario for occasions in which the main therapeutic objective would be metabolic normalization rather than reproductive rescue, as is actually the case for most women with PCOS, without pregnancy desire, which are submitted to continued hormonal contraception plus metformin treatment