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Given that vagal afferents innervate the ENS, it is plausible that the ENS can relay local intestinal signaling mechanisms to the CNS

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However, when combined with insulin or sulfonylureas, dose reduction of these agents may be necessary [6]

10.3892/ol.2016.5354 [DOI] [PMC free article] [PubMed] [Google Scholar] Liu Z., Dou W., Zheng Y., Wen Q., Qin M., Wang X., et al

At 12mg, 100% of participants achieved 5% weight loss and 83% achieved 15% weight loss, thresholds considered clinically meaningful in obesity medicine