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By binding to GLP-1 receptors in the pancreas, brain, and gut, semaglutide: Stimulates insulin release only when blood glucose is elevated, which significantly reduces hypoglycaemia risk compared to older diabetes drugs Suppresses glucagon reducing the livers release of stored glucose into the bloodstream Slows gastric emptying food leaves the stomach more slowly, producing prolonged fullness and reducing overall caloric intake Acts on the brains appetite centres reducing hunger signals and food cravings Mounjaro (Tirzepatide): Dual GLP-1 + GIP Receptor Agonist Tirzepatide activates the same GLP-1 receptor as semaglutide but also activates a second receptor: the glucose-dependent insulinotropic polypeptide (GIP) receptor

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provide compelling evidence that GLP-1 agonists are a safe and effective option in primary school-age children, bringing preventative medicine forward and taking a step closer to tackling obesity and improving population health

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