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By integrating genetic context with clinical evidence, you and your provider can engage in a data-informed discussion about phentermine versus GLP-1 suitability

Measurable weight loss typically appears within 24 weeks, with cumulative results accelerating over 812 weeks

This is another important benefit of GLP-1s, as kidney disease is a common complication of diabetes

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That flexibility matters because tirzepatide tends to produce stronger average weight loss for some patients, while others prefer semaglutide or want to avoid injections entirely