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Incretin mimetics as a novel therapeutic option for hepatic steatosis

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Future directions and research gaps Although GLP-1 therapies have revolutionized obesity and diabetes management, important knowledge gaps remain in optimizing their long-term safety, tolerability, and body composition outcomes

These effects are usually temporary and improve as the body adjusts

doi: 10.3390/ijms22020860 148 ZhangMWuYGaoRChenXChenRChenZ

While findings suggest a favorable therapeutic role and safety profile of GLP-1 RAs in managing overweight and obesity in IBD patients, limitations related to retrospective designs, small sample sizes, and potential risk of publication bias in most included studies underscore the need for larger prospective studies and randomized controlled trials