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While tirzepatide carries lower intrinsic hypoglycemia risk compared to insulin or sulfonylureas due to its glucose-dependent mechanism of action, the combination of fluid shifts during donation and potential meal timing disruptions may increase vulnerability to low blood glucose

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doi:10.1016/j.tcb.2015.04.002 2 Gomes AP, Price NL, Ling AZ, et al

After propensity score matching the GLP-1 cohort (n=45,704) included 35,753 (78.2%) women and 7,852 (17.2%) men with a mean age of 61.1, while the OWLD cohort (n=45,704) included 35,732 (78.2%) women and 7,815 (17.1%) men with a mean age of 61.0

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