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Most people notice a change in appetite and cravings within the first two to four weeks, even on the low 2.5mg starting dose. Visible weight loss is gradual and builds as your dose increases in trials, maximum average weight loss was reached around week 72. Steady, sustained loss is the goal rather than rapid drops

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In this case, the patient developed severe acute pancreatitis leading to death after four years of GLP-1RA use, with a dose increase occurring four weeks prior to admission

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