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Data availability The authors declare that all data supporting the findings of this study are available within the paper, Supplementary Information and the Source Data file

Renal impairment Semaglutide does not require dose adjustment for mild to moderate renal impairment

The oral semaglutide offered through MadeMed is a compounded sublingual formulation - it is not the same product, does not use the same proprietary absorption technology, and has not been independently evaluated by the FDA for bioavailability, dosing equivalence, or absorption characteristics relative to the FDA-approved version

doi: 10.1523/JNEUROSCI.0529-11.2011 66 HamiltonAHlscherC

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Today, there are three GLP-1 weight-loss drugs available: Saxenda