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45 for advanced lifters In one 2021 randomized control trial published in JAMA , individuals who combined calorie restriction with resistance training lost more fat and retained significantly more lean mass than those who dieted alone

Terrelonge M, Marder KS, Weintraub D, Alcalay RN

Morgan Healthcare Conference in January

TRT may also slightly improve baseline metabolic rate, which can enhance the weight loss response to GLP-1 agents by 510% in some studies, though individual variation is substantial

GLP-1 receptor agonists and inflammatory pathway modulation: Dual targeting of metabolic and immune dysfunction in insulin resistance

Focus on food quality and portion size to prevent nausea before it starts