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Nor-1, a novel incretin-responsive regulator of insulin genes and insulin secretion

Direct intraparenchymal delivery of low, ventricle subthreshold doses of GLP1R agonists to GLP1R expressing nuclei throughout the brain, including e.g., NTS, lPBN, ventral tegmental area (VTA), PVH, PVT, nucleus accumbens (NAcc), ventral hippocampus, and lateral septum reduced food intake via reductions in meal size

However, there is lack of RCTs in T1D using the newest generation of GLP-1RA or dual GLP-1/GIP agonists, which are associated with significantly more weight loss

While modafinil itself has been studied extensively and approved for specific medical uses, its analogues have not

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Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification