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Compliance with Ethics Guidelines This article is based on previously conducted studies and is not a new study with human participants or animals

Thus, this modest increase in LDL-C may be misleading regarding ASCVD risk, as patients with obesity may have a higher concentration of atherogenic small, dense LDL particles, and therefore high levels of apoB for a given blood LDL-C [10, 13]

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Weight loss achieved through appetite suppression shifts dietary patterns

Moreover, metformin enhanced cAMP production and inhibited incretin-induced CICR signaling