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Moreover, the rising prevalence of obesity and type 2 diabetes (T2D) globally continues to significantly boost market demand, as GLP-1 agonists play an essential role in the treatment and management of these conditions

In fact, the omitted study was a pooled analysis of 5 RCTs 196,197,198,199,200 of 5,325 patients with obesity followed for up to 3 years, which had shown that liraglutide was no different from placebo for depressive symptoms as scored on the Patient Health Questionnaire-9, while also highlighting a small increased risk of suicidal behavior 193

The future of obesity treatment with GLP-1 agonists will likely depend on continued therapeutic innovation and parallel advances in healthcare policy, delivery systems, and equity-focused implementation strategies