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Listening to my body was crucial if I felt full, I stopped eating, a concept that sometimes felt challenging before GLP-1

These outcomes occurred with drug exposure during periods of renal development in rats that correspond to the late second and third trimester of human renal development

On the other hand, it is still not entirely clear whether the hepatic effects of GLP-1 are direct or indirect, as recent studies have not clearly demonstrated the presence of GLP-1 receptors in human hepatocytes

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4.6 Future perspectives and translational potential Despite these limitations, the findings have immediate clinical implications

Constipation warrants particular attention , as inadequate fluid intake combined with reduced gut motility may contribute to discomfort and, theoretically, could exacerbate pre-existing diverticular disease, though this has not been definitively established