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To investigate the endogenous circuits mediating these behavioral responses, optogenetic studies revealed that GLP-1 excites medial habenula projections to the interpeduncular nucleus and that activation of GLP-1 receptors in this circuit is sufficient to attenuate nicotine consumption [190]

J., et al., RoB 2: A Revised Tool for Assessing Risk of Bias in Randomized Trials, BMJ (Clinical Research Ed.) 366 (2019): l4898

Gaps and Future Directions in Clinical Research on Obesity-Related Asthma

"Tirzepatide is contraindicated in patients with a personal or family history of MTC and in patients with multiple endocrine neoplasia syndrome type 2 (MEN 2)." Drugs.com A detailed medical screening is key to preventing complications
