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Description
The Lancet
The developing physiology of adolescents and the long-term nature of obesity treatment raise unique considerations
and inter alia, further down-regulates insulin function and thereby exacerbates Metabolic Syndrome

10.1016/j.cell.2018.09.048 56 LincoffA

In addition, high glucose levels significantly increase nicotinamide adenine dinucleotide phosphate (NADPH) oxidasedriven superoxide levels, contributing to the progression of heart failure [32]

At the same time, clinicians are getting a clearer sense of the side effects, mild and severe