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Women of reproductive age are disproportionately impacted, and obesity is strongly associated with infertility, pregnancy complications, and adverse neonatal outcomes, often mediated by metabolic disorders such as type 2 diabetes mellitus (T2DM) and polycystic ovary syndrome (PCOS) [1,2,3,4]

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Peng Zhong reported that MOTS-c prevented the development of heart failure via the activation of the AMPK pathway (34)

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Total calorie intake should not drop too fast

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Moreover, 44.3% of adults over 30 years of age have prediabetes with impaired fasting glucose or glycosylated hemoglobin (HbA1c) levels of 5.7% to 6.4% [1]

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