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GLP-1 medications are generally regarded as safe for most patients when prescribed by a qualified healthcare provider

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Pioglitazone improved cognition in a pilot study on patients with Alzheimers disease and mild cognitive impairment with diabetes mellitus

So, its possible that short-chain fatty acids produced in the colon are accessing the brain directly, and reducing appetite some other way

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Basal metabolic rate measures how many calories the body burns at rest