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Even though they have been proven to reduce the risk of major adverse cardiovascular events, their effectiveness in treating heart failure is unknown

The findings of a new study suggest that an apparent association between GLP-1 medications and thyroid cancer may be due to more intensive patient screening, and not a side effect of the drugs themselves.

Regarding renal effects, the evidence of SGLT2is in preventing kidney failure is more abundant than for GLP-1RAs, which showed a beneficial effect on albuminuria but not on hard kidney endpoints

Their potential for disease modification and symptom relief, particularly in specific phenotypes, supports their further exploration as part of a personalized treatment approach.

Thats why the FDA gives it a boxed warning

In recent years, there has been an increase in the morbidity, disability rate,and mortality due to obesity, making ...
