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In T2DM, agents such as semaglutide and tirzepatide effectively lower HbA1c levels, blood glucose levels, and body weight, outperforming conventional oral hypoglycemic agents and insulin

(26) GLP-1 agonists also demonstrated consistent reductions in lower limb amputation risk across subgroups, including those with peripheral arterial disease (PAD) and patients on antihypertensive therapy

Similar results were found in a clinical study in patients with T2DM, where administration of liraglutide, but not metformin, increased the relative abundance of Akkermansia , which is often associated with the improvement of gastric mucosa and also becomes severely depleted in diabetic patients [115]

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Verlust an Muskelmasse Beim Gewichtsverlust ist nicht nur Fett betroffen, sondern leider auch Muskelmasse etwa ein Drittel des verlorenen Gewichts

The study was recently published in the medical journal JAMA Network Open