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By activating GLP-1 receptors in the brain, semaglutide sends signals that promote feelings of fullness and reduce the desire to overeat

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[13] For the liver side specifically, researchers use hepatocyte lipid-loading models (exposing primary human hepatocytes or HepG2 cells to fatty acids such as oleate and palmitate to induce steatosis in a dish), hepatic stellate-cell lines (for example LX-2) to study fibrogenic activation, and increasingly three-dimensional systems liver organoids, spheroids, and liver-on-a-chip devices that better reproduce cellcell interactions

10.1161/STR.0b013e318296aeca 3

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