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Research from pharmaceutical stability testing shows GLP-1/GIP dual agonists lose 1218% potency per 24-hour period above the required storage range, with complete denaturation occurring within 72 hours at room temperature
Diabetes, obesity & metabolism, 24(8), 15531564

Consistent with systemic exendin-4 dose-response studies, the dose of intra-VTA exendin-4 (0.05 g) used in these studies reduced cocaine seeking and did not affect ad libitum chow intake or promote malaise-like effects in rats [67, 110, 131]

Scheen AJ (2023) Use of SGLT2 inhibitors after bariatric/metabolic surgery: risk/benefit balance