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Finally, although the alterations in ghrelin and GLP-1 signaling following bariatric interventions have been widely investigated, the direct causal contributions of these physiological changes to alterations in food reward-associated behaviors remain to be determined

That was the whole point

The psychological impact of achieving health goals and regaining a sense of control over one's health should not be underestimated
Clinical trials used in drug development are sometimes described by phase

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doi: 10.1056/NEJMoa2028395
