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The most common side effects are gastrointestinal: nausea (~45%), diarrhea (~22%), constipation (~15%), and vomiting (~13%)

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During this 72-hour period, body weight and food intake were daily monitored, and oxygen consumption (VO 2 ) and carbon dioxide production (VCO 2 ) were measured every 9 min

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GLP-1 drugs such as semaglutide are much larger, protein-like molecules

Presynaptic Modulation of Neurotransmitter Release GLP-1R modulates synaptic transmission by regulating presynaptic glutamate and GABA release, thereby influencing neural circuits involved in energy balance, cognition, and emotional regulation