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[5] [9] This cautious approach reflects the precautionary principle applied when safety data are lacking rather than evidence of actual harm

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Cardiovascular outcome studies were not required for the approval of pramlintide, and the available preclinical data are insufficient to predict whether amylin agonism will impact cardiovascular pathophysiology in susceptible individuals

Native GLP-1 was recognized as a potential drug target by the late 1980s

[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Strong J, Driscoll MS

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