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Both medications have their roles in obesity management, and the choice between the two will often fall on individual patient needs, preferences, medical history, and a healthcare providers recommendation

In clinical applications, in addition to treating T2DM, metformin has been found to be effective in certain diseases, such as obesity, cardiovascular disease, IBD, and other inflammation-related diseases

The excess escapes as sulfur burps
While GLP-1R expression in the GI tract is classically ascribed to the myenteric plexus, the highest level of GLP-1R expression in the gut is in the Brunner's glands in the upper duodenum (73, 87)

But this time, they have a body of work to build on
