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GLP-1 receptors are found on various immune cells, including T-cells and macrophages

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As demonstrated by oxyntomodulin, a weak endogenous agonist for GLP-1 receptor and glucagon receptor, a strategy that simultaneously stimulates both GLP-1 and glucagon receptors can reduce food intake while increasing energy expenditure, synergistically enhancing weight loss [105-107]

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Prolonged glucagon infusion does not affect energy expenditure in individuals with overweight/obesity: a randomized trial

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Food intake and body weight in each experimental group (diabetic WCDD301-treated, diabetic placebo-treated, and nondiabetic placebo-treated NOD mice) were monitored daily for 4 weeks

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doi: 10.1161/CIRCULATIONAHA.118.038771

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