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In real-world clinical practice, endocrinologists frequently prescribe semaglutide to patients already on metformin, particularly those with type 2 diabetes seeking greater weight reduction or glycemic improvement

A broader perspective on tirzepatide in the context of other weight management peptides is available through our peptides for fat loss overview and our ranking of the best peptides for weight loss

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Key features and findings about liraglutide include: Glycemic Efficacy: Liraglutide showed greater A1c reduction than exenatide in trials

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Beyond weight loss, tirzepatide also demonstrated significant improvements in fasting insulin, blood pressure, lipid profiles, and overall glycaemic control, reinforcing its potential role in long-term metabolic health management