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Current evidence suggests GLP-1 drugs like semaglutide do not directly harm sperm production, though weight loss itself can improve hormonal markers and fertility outcomes

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After adjustment for baseline covariates, semaglutide was associated with greater weight reduction and LDL cholesterol improvement, whereas HbA1c reduction was comparable between groups

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The procedure works by renewing the lining of the upper small intestine, potentially resetting metabolism and preserving the benefits of weight loss.
