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PVN, paraventricular nucleus

The complete list of analyzed PTs is provided in Supplementary Table 2

During the intensive lifestyle intervention lead-in period, lifestyle instruction was delivered 8 times over 12 weeks by a dietician or dietician-equivalent, with all patients receiving instruction to exercise for at least 150 minutes per week and to reduce their caloric intake to approximately 1,200 kcal/day (females) or 1,500 kcal/day (males)

Zepbound (Tirzepatide): This is the only dual agonist currently on the market, targeting both GLP-1 and GIP receptors

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