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While anti-inflammatory and neuroprotective effects of GLP-1 receptor agonists have been described, it remains unclear to what extent these benefits are attributable to peripheral metabolic improvements (e.g., weight loss, improved insulin sensitivity) versus direct central actions on brain circuits

Through coordinated GLP-1R and GIPR activation, tirzepatide enhances glucose-dependent insulin secretion, improves glycemic control, contributes to lipid homeostasis, and reduces appetite and food intake, supporting its clinical use in obesity and type 2 diabetes [13]

Clinical trials have shown promising results, highlighting its effectiveness in improving glycemic control and aiding weight loss in individuals with Type 2 diabetes and obesity

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[DOI] [PMC free article] [PubMed] [Google Scholar] 421.Al-Sabah S., Donnelly D

Conclusions The field of bone health and GLP-1Ra is evolving rapidly