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July 7, 2025

Safety and Tolerability of Glucagon-Like Peptide-1 Receptor Agonists: A State-of-the-Art Narrative Review

Animal studies have demonstrated that GLP-1 receptor agonists can increase sympathetic nerve activity, particularly to the heart and kidneys

When the effort required by rodents to obtain palatable food was assessed, exendin-4 was found to decrease operant responding on both fixed and progressive ratio schedules, further supporting a reduction in the motivational drive for palatable foods ( However, it is worth noting that most preclinical studies do not incorporate a dose titration phase, a gradual increase to the therapeutic maintenance dose, which is standard in clinical settings

Weekend meals tend to be less structured, more social, and higher in temptation

Polyphenolic compounds are divided into phenolic acids, phenolic alcohols, flavonoids, stilbenoids, and lignans [188]