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Research suggests it can

Discontinuation or cycling on and off GLP1RAs and tirzepatide might increase long-term cardiovascular risk by promoting variability in weight and HbA 1c

This has shifted the focus to treating the patient, and not necessarily lab values or numbers

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As hinted above, this predicament could be disentangled via studies that include a mechanistic assessment of biomarkers predicting response versus harm following GLP-1RA administration 192