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rxlist.com (Byetta ) rxlist.com (Byduron ) extended release formulation Keywords Liraglutide Trade Names: Victoza & generic Pharmacology: GLP-1 analog mechanism of action is the same as exenatide Indications: an adjunct to diet and exercise to improve glycemic control in type 2 diabetes mellitus to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) in adults with type 2 diabetes mellitus and established cardiovascular disease Pharmacokinetics: once-daily injection Side Effects: Most common : nausea, diarrhea, vomiting (similar to exenatide) Black Box Warning: RISK OF THYROID C-CELL TUMORS References: Masharani U, Kroon L (2024): Pancreatic Hormones & Antidiabetic Drugs (Chapter 41)

This innovative treatment synergistically combines a fully human monoclonal antibody, aimed at the GIP receptor (GIPR) a target for blood sugar control with a GLP-1 agonist peptide analog , which is a molecule designed to stimulate insulin release [Vniant, M.M

[DOI] [PMC free article] [PubMed] [Google Scholar] 91.Shetty R, Basheer FT, Poojari PG, Thunga G, Chandran VP, Acharya LD

[DOI] [PMC free article] [PubMed] [Google Scholar] 11

24,29 Through this receptor, GLP-1 leads to an increase of cAMP levels that thereafter activates protein kinase A (PKA)

However, at present primary care staff cannot prescribe GLP-1 RA for obesity and currently must refer patients to specialist weight management services