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In crude analyses, GLP-1 receptor agonist use was associated with an increased incidence of suicidality compared with DPP-4 inhibitors (crude incidence rates 3.9 v 1.8 per 1000 person years, respectively

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Semaglutide restored GSK3-Drp1 signalling, maintained mitochondrial membrane potential, and decreased mitochondrial fragmentation in primary cardiomyocytes via GLP-1R activation

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Wegovy users report an average weight loss of 15-22% of body weight in clinical trials, with some patients losing more than 50 pounds